PSORIASIS & ECZEMA SKIN

Ceramides and Skin Disease

Eczema sufferers have significantly fewer ceramides in their Stratum Corneum.

Psoriasis sufferers in contrast have the same number of ceramides compared to people with normal skin. However, the psoriasis-sufferers have less ceramide 1, 3, 4, and a sub-set of 5 and 6; and more ceramide 2 and another sub-set of 5. 

Replacing Ceramides improves eczema. Recent studies have shown that lipids can be replaced with topical preparations. 

Interestingly, all three lipids have to be replaced at a certain ratio to restore the barrier function of the skin. If the incorrect balance of lipids is applied, it actually takes longer for the skin to heal. The effect of ceramides has been studied in eczema, but there are also interesting outcomes being seen with psoriasis management.

Trans Epidermal Water Loss happens in everyone but is usually abnormal and excessive in people withskin issues , ageing skin, sun damaged skin, and many skin conditionsranging from acne, eczema , psoriasis, ichthyosis.

Ceramides play an important part in controlling cellular water loss and skin water loss. Water loss leads to dehydration. Dehydration impairs cellular function, cell communication and increases cell stress and can hasten cell death.

Skin can respond to dehydration by increasing skin lipid content to compensate, but in some this response is impaired and instead the skin can crack and dry. In other situations/types who have or develop a lipid and ceramide deficiency, liquid oil (sebum) production is increased, skin cell production increases to thicken the skin and increased keratin production creates an increased barrier to water loss (the horny layer). As the stratum corneum also lines the neck of the hair follicle duct, then as it thickens here, this leads to a closure (blocking) of the duct and then the development of black heads and then through bacterial colonisation of the blocked duct;  acne.

PSORIASIS & ECZEMA SKIN

Ceramides and Skin Disease

Eczema sufferers have significantly fewer ceramides in their Stratum Corneum.

Psoriasis sufferers in contrast have the same number of ceramides compared to people with normal skin. However, the psoriasis-sufferers have less ceramide 1, 3, 4, and a sub-set of 5 and 6; and more ceramide 2 and another sub-set of 5. 

 

Replacing Ceramides improves eczema. Recent studies have shown that lipids can be replaced with topical preparations. 

 

Interestingly, all three lipids have to be replaced at a certain ratio to restore the barrier function of the skin. If the incorrect balance of lipids is applied, it actually takes longer for the skin to heal. The effect of ceramides has been studied in eczema, but there are also interesting outcomes being seen with psoriasis management.

 

Trans Epidermal Water Loss happens in everyone but is usually abnormal and excessive in people with skin issues , ageing skin, sun damaged skin, and many skin conditions ranging from acne, eczema , psoriasis, ichthyosis.

 

Ceramides play an important part in controlling cellular water loss and skin water loss. Water loss leads to dehydration. Dehydration impairs cellular function, cell communication and increases cell stress and can hasten cell death.

 

Skin can respond to dehydration by increasing skin lipid content to compensate, but in some this response is impaired and instead the skin can crack and dry. In other situations/types who have or develop a lipid and ceramide deficiency, liquid oil (sebum) production is increased, skin cell production increases to thicken the skin and increased keratin production creates an increased barrier to water loss (the horny layer).

 

As the stratum corneum also lines the neck of the hair follicle duct, then as it thickens here, this leads to a closure (blocking) of the duct and then the development of black heads and then through bacterial colonisation of the blocked duct;  acne.